Epithelial cell fate commitment

Across TCGA cell cohorts, RNA activity of the Epithelial cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACVR1, NRP1, and RARA, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell fate commitment activity versus ACVR1 in SOFT_TISSUE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ACVR1 →	+0.966	+0.160	<.001	<.001	3	17
LUNG_NSCLC_LUSC	NRP1 →	+2.761	+0.185	<.001	<.001	3	15
KIDNEY	RARA →	+1.145	+0.169	<.001	<.001	3	14
BONE	CAPN2 →	+1.782	+0.206	.001	<.001	3	14
BONE	GLIPR1 →	+3.983	+0.230	<.001	<.001	3	13
BONE	SP100 →	+2.879	+0.153	.001	.009	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072148 vs ACVR1 — SOFT_TISSUE

Explore this scatter interactively →