Glomerular mesangial cell development

Across TCGA patient cohorts, RNA activity of the Glomerular mesangial cell development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ILK, RSU1, and ITGA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular mesangial cell development activity versus ILK in BRCA (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ILK →	+0.381	+0.044	<.001	<.001	3	7
BRCA	RSU1 →	+0.401	+0.059	<.001	<.001	3	6
OV	ITGA1 →	+0.438	+0.056	.005	.004	3	6
CCRCC	NCK2 →	+0.262	+0.075	.001	<.001	3	6
LSCC	MYH9 →	+0.376	+0.107	<.001	<.001	3	5
GBM	SEPTIN4 →	+0.576	+0.068	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072144 vs ILK — BRCA

Explore this scatter interactively →