Glomerular mesangial cell development

Across TCGA patient cohorts, RNA activity of the Glomerular mesangial cell development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFAP2, CPXM2, and PDLIM4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular mesangial cell development activity versus MFAP2 in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MFAP2 →	+0.773	+0.387	<.001	<.001	3	3
BRCA	CPXM2 →	+1.180	+0.413	<.001	.007	3	3
BRCA	PDLIM4 →	+0.694	+0.343	.002	.001	3	3
BRCA	GYPC →	+0.619	+0.414	.002	.006	3	3
BRCA	FXYD6 →	+0.643	+0.636	<.001	<.001	3	3
BRCA	MFGE8 →	+0.844	+0.431	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072144 vs MFAP2 — BRCA

Explore this scatter interactively →