Glomerular mesangial cell development

Across TCGA cell cohorts, RNA activity of the Glomerular mesangial cell development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R3B, OXCT2, and METTL2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R3B grouped by Glomerular mesangial cell development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP1R3B →	-1.380	-0.919	.004	.003	3	4
LUNG_NSCLC_LUAD	OXCT2 →	+0.356	+0.695	.001	.001	3	4
BONE	METTL2A →	+0.520	+1.261	.001	.001	3	4
SKIN	GCHFR →	+1.027	+1.091	<.001	<.001	3	3
SKIN	TMEM170B →	+0.656	+0.980	<.001	.004	3	3
CNS	SNX27 →	+0.327	+1.147	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R3B by Glomerular mesangial cell development activity — LARGE_INTESTINE

Explore this box plot interactively →