Mesenchyme morphogenesis

Across TCGA cell cohorts, RNA activity of the Mesenchyme morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FDXR, COMMD2, and ACBD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FDXR grouped by Mesenchyme morphogenesis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FDXR →	+1.925	+0.391	<.001	<.001	3	4
KIDNEY	COMMD2 →	-0.617	-0.297	.001	.004	3	3
BONE	ACBD4 →	+1.444	+0.192	.003	<.001	2	4
STOMACH	DYRK4 →	+1.253	+0.400	.004	.005	3	3
STOMACH	RBM39 →	-0.795	-0.386	.006	.006	2	4
OVARY	HIVEP3 →	+0.868	+0.424	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FDXR by Mesenchyme morphogenesis activity — OVARY

Explore this box plot interactively →