Positive regulation of glomerular mesangial cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of glomerular mesangial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC2B, EMP3, and DCN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glomerular mesangial cell proliferation activity versus CLEC2B in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLEC2B →	+0.993	+0.278	<.001	<.001	3	6
COAD	EMP3 →	+0.937	+1.057	<.001	.001	3	6
BRCA	DCN →	+1.132	+0.256	<.001	.001	3	5
BRCA	C1S →	+1.136	+0.295	<.001	.005	3	5
COAD	LINC01705 →	+1.196	+0.834	.002	.004	3	5
BRCA	IFFO1 →	+0.527	+0.224	.008	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072126 vs CLEC2B — BRCA

Explore this scatter interactively →