Positive regulation of glomerular mesangial cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of glomerular mesangial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA3C, CCDC9B, and BHLHE40, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEMA3C grouped by Positive regulation of glomerular mesangial cell proliferation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SEMA3C →	+3.241	+1.528	.004	.003	3	5
LUNG_SCLC	CCDC9B →	+2.297	+1.367	.007	.004	2	6
LUNG_SCLC	BHLHE40 →	+2.277	+1.273	.003	.006	3	4
SOFT_TISSUE	PORCN →	+1.414	+1.434	.001	.006	2	5
STOMACH	ZNF189 →	-0.788	-1.031	.004	.004	3	3
PANCREAS	C15orf48 →	+3.193	+0.750	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEMA3C by Positive regulation of glomerular mesangial cell proliferation activity — BONE

Explore this box plot interactively →