Cell proliferation involved in kidney development

Across TCGA patient cohorts, RNA activity of the Cell proliferation involved in kidney development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SL491P, TMSB4XP3, and CACYBPP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell proliferation involved in kidney development activity versus RN7SL491P in LSCC (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RN7SL491P →	+0.172	+0.563	.003	<.001	3	3
LUAD	TMSB4XP3 →	+0.238	+0.535	.004	.008	3	3
BRCA	CACYBPP1 →	-0.141	-0.530	<.001	<.001	3	2
OV	XRCC4 →	+0.423	+0.318	.001	.007	3	2
OV	NTAN1 →	+0.364	+0.379	.004	.001	3	2
OV	PCF11 →	-0.379	-0.316	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072111 vs RN7SL491P — LSCC

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