Glomerular mesangium development

Across TCGA patient cohorts, RNA activity of the Glomerular mesangium development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYGB, SNX9, and TLN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular mesangium development activity versus CYGB in OV (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYGB →	+0.745	+0.080	<.001	<.001	3	10
BRCA	SNX9 →	+0.343	+0.053	<.001	<.001	3	9
UCEC	TLN1 →	+0.542	+0.078	<.001	.001	3	9
UCEC	GUCY1B1 →	+0.444	+0.075	<.001	<.001	3	9
OV	PRKG1 →	+0.699	+0.075	<.001	<.001	3	9
OV	RAI14 →	+0.466	+0.066	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072109 vs CYGB — OV

Explore this scatter interactively →