Glomerular mesangium development

Across TCGA patient cohorts, RNA activity of the Glomerular mesangium development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ICAM2, RGS2, and C8orf88, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular mesangium development activity versus ICAM2 in CCRCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ICAM2 →	+0.451	+0.360	.008	.004	3	4
COAD	RGS2 →	+0.729	+0.469	.002	.001	3	4
BRCA	C8orf88 →	+0.471	+0.750	.003	<.001	3	4
UCEC	ARHGAP20 →	+0.660	+0.702	.007	.003	3	4
PDAC	KCNE4 →	+0.605	+0.694	.001	.001	3	4
OV	CD34 →	+0.655	+0.582	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072109 vs ICAM2 — CCRCC

Explore this scatter interactively →