Glomerular mesangium development

Across TCGA cell cohorts, RNA activity of the Glomerular mesangium development pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCGF1, ORMDL1, and DAPL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCGF1 grouped by Glomerular mesangium development-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PCGF1 →	-0.238	-0.219	.003	.002	3	3
UPPER_AERODIGESTIVE_TRACT	ORMDL1 →	+0.213	+0.180	.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	DAPL1 →	-0.178	-0.195	.003	.002	3	3
SKIN	PSMA4 →	+0.237	+0.619	.007	.001	3	3
LUNG_SCLC	CDK14 →	-0.187	-0.978	.001	.006	3	3
BLOOD_Myeloma	NUP58 →	-0.649	-1.699	.006	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCGF1 by Glomerular mesangium development activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →