Glomerulus vasculature morphogenesis

Across TCGA patient cohorts, RNA activity of the Glomerulus vasculature morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINF1, TIMP2, and AEBP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerulus vasculature morphogenesis activity versus SERPINF1 in OV (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINF1 →	+0.780	+0.128	<.001	<.001	3	8
BRCA	TIMP2 →	+0.651	+0.077	<.001	<.001	3	8
OV	AEBP1 →	+0.767	+0.136	<.001	<.001	3	8
OV	COL1A1 →	+0.932	+0.141	<.001	<.001	3	8
LSCC	COL3A1 →	+0.675	+0.112	<.001	<.001	3	8
BRCA	ECM2_S213 →	+0.810	+0.069	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072103 vs SERPINF1 — OV

Explore this scatter interactively →