Glomerulus vasculature morphogenesis

Across TCGA patient cohorts, RNA activity of the Glomerulus vasculature morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLSCR4, PLA2G5, and RBM39P1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerulus vasculature morphogenesis activity versus PLSCR4 in LUAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLSCR4 →	+0.353	+0.284	.004	.009	3	3
LUAD	PLA2G5 →	+0.379	+0.432	.001	.003	3	3
LUAD	RBM39P1 →	-0.156	-0.466	<.001	.001	3	3
CCRCC	TERF1P5 →	-0.037	-0.378	.001	.006	3	3
COAD	ADPRH →	+0.351	+0.517	.006	.008	3	3
COAD	NLRC3 →	+0.349	+0.416	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072103 vs PLSCR4 — LUAD

Explore this scatter interactively →