Glomerulus vasculature morphogenesis

Across TCGA cell cohorts, RNA activity of the Glomerulus vasculature morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP300, FBXW4, and FAM216A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CFAP300 grouped by Glomerulus vasculature morphogenesis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CFAP300 →	+1.610	+0.633	<.001	.004	3	3
BREAST	FBXW4 →	-0.830	-0.812	<.001	.001	3	3
STOMACH	FAM216A →	+1.141	+0.752	.008	.004	3	3
SKIN	CTSS →	-1.512	-0.939	.003	.004	3	3
CNS	KIAA1671 →	-1.440	-1.155	<.001	<.001	3	3
BLOOD_Leukemia	MPP6 →	+1.835	+1.100	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CFAP300 by Glomerulus vasculature morphogenesis activity — SOFT_TISSUE

Explore this box plot interactively →