Glomerulus vasculature morphogenesis

Across TCGA cell cohorts, RNA activity of the Glomerulus vasculature morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SESTD1, MIOX, and PNPLA3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerulus vasculature morphogenesis activity versus SESTD1 in SOFT_TISSUE (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SESTD1 →	+2.040	+1.544	.008	.004	2	2
CNS	MIOX →	+0.195	+1.924	<.001	<.001	3	1
CNS	PNPLA3 →	+1.792	+1.622	.003	<.001	3	1
CNS	ABHD4 →	+1.467	+1.836	.003	<.001	3	1
CNS	NFATC4 →	+3.701	+1.622	<.001	<.001	3	1
CNS	NDUFAF5 →	-0.550	-1.328	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072103 vs SESTD1 — SOFT_TISSUE

Explore this scatter interactively →