Glomerulus morphogenesis

Across TCGA patient cohorts, RNA activity of the Glomerulus morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCSD1, CASS4, and S100Z, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerulus morphogenesis activity versus RCSD1 in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCSD1 →	+0.511	+0.368	.003	.002	3	5
LUAD	CASS4 →	+0.589	+0.376	.001	.003	3	5
LUAD	S100Z →	+0.299	+0.407	.003	.004	3	5
LSCC	CXCR4 →	+0.505	+0.299	.005	.005	3	4
LUAD	SERPINF1 →	+0.592	+0.349	.002	.001	3	4
LSCC	CD53 →	+0.554	+0.265	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072102 vs RCSD1 — LSCC

Explore this scatter interactively →