Glomerulus morphogenesis

Across TCGA cell cohorts, RNA activity of the Glomerulus morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHP1P2, CIC, and CBWD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHP1P2 grouped by Glomerulus morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CHP1P2 →	+0.318	+0.277	.001	.002	3	3
OVARY	CIC →	+0.183	+0.266	.002	<.001	2	4
UPPER_AERODIGESTIVE_TRACT	CBWD2 →	+0.206	+0.299	.006	.002	3	3
BONE	IDUA →	-0.183	-0.232	<.001	<.001	3	3
LIVER	HTATSF1 →	+0.546	+0.148	.001	.002	3	3
LIVER	ARHGEF40 →	+0.304	+0.166	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHP1P2 by Glomerulus morphogenesis activity — CNS

Explore this box plot interactively →