Glomerulus morphogenesis

Across TCGA cell cohorts, RNA activity of the Glomerulus morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XBP1, CARD14, and JAZF1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerulus morphogenesis activity versus XBP1 in BLOOD_Leukemia (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	XBP1 →	+0.649	+1.868	.004	.001	3	2
BLOOD_Leukemia	CARD14 →	+0.463	+1.868	.003	.001	3	2
BLOOD_Leukemia	JAZF1 →	+2.480	+2.211	.001	.004	3	2
BLOOD_Leukemia	GMPS →	+0.816	+1.868	.006	.001	3	2
BLOOD_Leukemia	TMEM41A →	+0.666	+1.868	.004	.001	3	2
BLOOD_Leukemia	GRAMD1C →	+0.400	+1.868	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072102 vs XBP1 — BLOOD_Leukemia

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