Regulation of stem cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of stem cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD109, TIMP2, and ACTN1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stem cell proliferation activity versus CD109 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD109 →	+0.833	+0.038	<.001	<.001	3	9
BRCA	TIMP2 →	+0.676	+0.028	<.001	<.001	3	8
CCRCC	ACTN1 →	+0.512	+0.042	<.001	<.001	3	8
OV	CNN2 →	+0.839	+0.039	<.001	<.001	3	8
OV	ITGA5 →	+0.648	+0.037	<.001	<.001	3	8
CCRCC	PXDN →	+0.707	+0.041	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072091 vs CD109 — GBM

Explore this scatter interactively →