Regulation of stem cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF10, LDLRAD3, and TRO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stem cell proliferation activity versus TAF10 in CCRCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TAF10 →	+0.257	+0.146	<.001	.003	3	5
UCEC	LDLRAD3 →	+0.596	+0.144	<.001	<.001	3	5
UCEC	TRO →	+0.780	+0.156	.004	.001	3	5
CCRCC	LINC02664 →	+0.455	+0.181	<.001	.001	3	5
CCRCC	ZEB1 →	+0.583	+0.194	<.001	.001	3	4
GBM	TTC28-AS1 →	+0.370	+0.156	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072091 vs TAF10 — CCRCC

Explore this scatter interactively →