Regulation of stem cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KPNA5, DYRK1A, and SLAIN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stem cell proliferation activity versus KPNA5 in BLOOD_Lymphoma (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KPNA5 →	+1.080	+0.184	<.001	.008	3	5
BLOOD_Lymphoma	DYRK1A →	+0.577	+0.175	<.001	.002	3	5
LIVER	SLAIN1 →	+2.554	+0.429	<.001	.006	3	5
BONE	SOBP →	+0.966	+0.240	.003	.005	3	5
OVARY	SPRED2 →	+0.940	+0.254	.002	.002	3	4
BLOOD_Leukemia	RPA1 →	+0.587	+0.130	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072091 vs KPNA5 — BLOOD_Lymphoma

Explore this scatter interactively →