Stem cell proliferation

Across TCGA cell cohorts, RNA activity of the Stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF841, UACA, and STK35, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF841 grouped by Stem cell proliferation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZNF841 →	+1.405	+0.881	.001	.006	3	4
LUNG_NSCLC_LUSC	UACA →	-1.261	-1.122	.007	<.001	3	4
BREAST	STK35 →	+0.890	+0.833	.003	.007	3	3
BREAST	ZCCHC3 →	+0.572	+0.517	.002	.006	3	3
BLOOD_Lymphoma	SCPEP1 →	-1.712	-1.378	.002	.006	3	3
BLOOD_Lymphoma	DSTN →	-2.650	-1.783	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF841 by Stem cell proliferation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →