Renal vesicle development

Across TCGA patient cohorts, RNA activity of the Renal vesicle development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NDUFAF2, SH3PXD2B, and SOX9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal vesicle development activity versus NDUFAF2 in LSCC (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NDUFAF2 →	-0.320	-0.054	.001	.001	3	6
LUAD	SH3PXD2B →	+0.292	+0.065	.002	.001	3	5
LUAD	SOX9 →	+0.782	+0.061	.002	.004	2	6
LSCC	UIMC1 →	-0.292	-0.072	.001	<.001	3	5
LUAD	WIPF3 →	+1.050	+0.118	<.001	.002	3	5
LUAD	BPI →	+0.691	+0.084	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072087 vs NDUFAF2 — LSCC

Explore this scatter interactively →