Renal vesicle development

Across TCGA patient cohorts, RNA activity of the Renal vesicle development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LEPROT, PRKD1, and SEC23A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal vesicle development activity versus LEPROT in LSCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LEPROT →	+0.371	+0.965	<.001	<.001	3	4
GBM	PRKD1 →	+0.527	+0.485	.001	<.001	3	4
BRCA	SEC23A →	+0.653	+0.479	.002	.008	3	3
BRCA	LOX →	+0.975	+0.516	.002	.005	3	3
BRCA	GNB4 →	+0.772	+0.559	.001	.007	3	3
BRCA	CALD1 →	+0.850	+0.533	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072087 vs LEPROT — LSCC

Explore this scatter interactively →