Nephron tubule formation

Across TCGA patient cohorts, RNA activity of the Nephron tubule formation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AHNAK_S5448, ADARB1, and CXCL12, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nephron tubule formation activity versus AHNAK_S5448 in CCRCC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AHNAK_S5448 →	-0.697	-0.129	<.001	<.001	3	7
CCRCC	ADARB1 →	-0.234	-0.118	.001	<.001	3	6
UCEC	CXCL12 →	-0.604	-0.087	.004	.004	3	6
GBM	ITGA4 →	-0.556	-0.131	<.001	<.001	3	6
BRCA	RASA3 →	-0.250	-0.059	<.001	<.001	3	6
UCEC	SNX9 →	-0.256	-0.090	.002	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072079 vs AHNAK_S5448 — CCRCC

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