Nephron tubule formation

Across TCGA patient cohorts, RNA activity of the Nephron tubule formation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF250, ZNF606, and MASP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nephron tubule formation activity versus ZNF250 in LUAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZNF250 →	+0.455	+0.631	<.001	.002	3	5
BRCA	ZNF606 →	+0.499	+0.502	.002	.009	3	4
LUAD	MASP2 →	+0.658	+0.774	<.001	<.001	3	4
LUAD	IGIP →	+0.472	+0.623	<.001	<.001	3	4
LUAD	RN7SL329P →	+0.366	+0.614	.008	.002	3	4
OV	PPIAP49 →	+0.155	+0.667	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072079 vs ZNF250 — LUAD

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