Nephron tubule formation

Across TCGA cell cohorts, RNA activity of the Nephron tubule formation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFR1, CDX2, and ADAM29, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SFR1 grouped by Nephron tubule formation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SFR1 →	-0.227	-1.413	.007	.001	3	3
LUNG_NSCLC_LUSC	CDX2 →	+0.088	+1.506	.005	.008	3	3
LUNG_NSCLC_LUSC	ADAM29 →	+0.219	+1.579	.003	.006	3	3
BREAST	CD22 →	-0.147	-0.319	.009	.006	3	3
STOMACH	DUSP16 →	+0.146	+0.291	.002	.001	3	3
STOMACH	RAB1A →	+0.168	+0.163	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SFR1 by Nephron tubule formation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →