Metanephric mesenchyme development

Across TCGA patient cohorts, RNA activity of the Metanephric mesenchyme development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZYX, UBR5, and LMOD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric mesenchyme development activity versus ZYX in LSCC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZYX →	-0.187	-0.070	.003	<.001	3	7
LSCC	UBR5 →	+0.206	+0.078	.001	.001	3	6
CCRCC	LMOD1 →	-0.746	-0.065	.003	.006	3	6
BRCA	MSRB3 →	-0.445	-0.048	.006	.002	3	6
UCEC	TBC1D13 →	-0.327	-0.117	.001	<.001	3	6
LSCC	MORC2 →	+0.352	+0.084	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072075 vs ZYX — LSCC

Explore this scatter interactively →