Kidney mesenchyme development

Across TCGA patient cohorts, RNA activity of the Kidney mesenchyme development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZYX, MPHOSPH10, and PUS7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kidney mesenchyme development activity versus ZYX in LSCC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZYX →	-0.350	-0.088	<.001	<.001	3	7
LSCC	MPHOSPH10 →	+0.340	+0.077	<.001	<.001	3	7
LSCC	PUS7 →	+0.287	+0.053	.002	<.001	3	7
GBM	ZYX_S344 →	-0.372	-0.055	.006	.007	3	6
HNSC	ADARB1_S26 →	-0.582	-0.080	<.001	<.001	3	6
CCRCC	AEBP1 →	-0.644	-0.043	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072074 vs ZYX — LSCC

Explore this scatter interactively →