Kidney mesenchyme development

Across TCGA patient cohorts, RNA activity of the Kidney mesenchyme development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01346, IKBIP, and TRIP13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kidney mesenchyme development activity versus LINC01346 in UCEC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01346 →	-0.445	-0.441	.005	.007	3	4
UCEC	IKBIP →	+0.343	+0.454	.003	.008	2	5
LSCC	TRIP13 →	+0.409	+0.261	.009	<.001	3	4
OV	PODNL1 →	+0.776	+0.563	.001	<.001	3	4
OV	ITPRIPL1 →	+0.445	+0.539	.001	.001	3	4
COAD	C1QBP →	+0.495	+0.382	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072074 vs LINC01346 — UCEC

Explore this scatter interactively →