Kidney mesenchyme development

Across TCGA cell cohorts, RNA activity of the Kidney mesenchyme development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC22, CDKL1, and PYY, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC22 grouped by Kidney mesenchyme development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CCDC22 →	+0.490	+1.268	.007	<.001	3	5
LUNG_SCLC	CDKL1 →	+1.947	+1.387	.002	<.001	3	4
BLOOD_Myeloma	PYY →	-0.056	-1.037	<.001	.004	3	4
LUNG_NSCLC_LUSC	CYP2S1 →	+3.257	+1.393	.007	.006	3	4
SOFT_TISSUE	PECR →	+1.124	+1.258	.002	.006	3	3
SOFT_TISSUE	APEX2 →	-0.651	-1.307	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC22 by Kidney mesenchyme development activity — SKIN

Explore this box plot interactively →