Kidney epithelium development

Across TCGA cell cohorts, RNA activity of the Kidney epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECHS1, CALB2, and RAVER2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ECHS1 grouped by Kidney epithelium development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ECHS1 →	+0.332	+0.549	.007	.002	3	3
BREAST	CALB2 →	-2.513	-0.826	<.001	<.001	3	3
SKIN	RAVER2 →	+0.647	+0.729	.001	.009	3	3
SOFT_TISSUE	ST3GAL6 →	-1.475	-1.068	.004	.006	3	3
BONE	CHCHD6 →	+0.669	+1.321	.008	.007	3	3
LUNG_NSCLC_LUAD	STAB1 →	-0.117	-0.843	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ECHS1 by Kidney epithelium development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →