Kidney epithelium development

Across TCGA cell cohorts, RNA activity of the Kidney epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C16orf74, CDA, and APOL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kidney epithelium development activity versus C16orf74 in KIDNEY (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	C16orf74 →	+1.639	+0.375	.005	.007	3	6
BREAST	CDA →	+2.787	+0.257	<.001	<.001	3	5
BREAST	APOL3 →	+2.071	+0.248	<.001	<.001	3	5
OESOPHAGUS	LCN2 →	+4.482	+0.310	.001	.006	3	5
OVARY	RHBDL2 →	+2.293	+0.390	<.001	.005	3	5
OVARY	TACSTD2 →	+4.688	+0.391	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072073 vs C16orf74 — KIDNEY

Explore this scatter interactively →