Loop of Henle development

Across TCGA patient cohorts, RNA activity of the Loop of Henle development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRX2, COP1, and DSG3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Loop of Henle development activity versus IRX2 in BRCA (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IRX2 →	+1.371	+0.389	<.001	<.001	3	4
UCEC	COP1 →	-0.456	-0.603	.009	.006	3	3
LSCC	DSG3 →	+2.437	+0.321	<.001	.008	3	3
GBM	SLITRK1 →	-1.032	-0.287	.001	.005	3	3
HNSC	CYFIP2 →	-0.581	-0.274	<.001	.003	2	4
CCRCC	WNT2B →	+0.661	+0.635	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072070 vs IRX2 — BRCA

Explore this scatter interactively →