Loop of Henle development

Across TCGA patient cohorts, RNA activity of the Loop of Henle development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRAF3IP1_S476, CIAO2B, and IRX2_S286, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Loop of Henle development activity versus TRAF3IP1_S476 in LUAD (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRAF3IP1_S476 →	+0.242	+0.264	<.001	.002	3	3
HNSC	CIAO2B →	-0.309	-0.429	.001	.001	3	3
BRCA	IRX2_S286 →	+1.019	+0.480	<.001	<.001	3	3
LSCC	JAG1 →	+1.051	+0.509	<.001	<.001	3	3
OV	DBI →	-1.994	-1.049	<.001	<.001	3	3
OV	IKBIP →	+0.440	+0.961	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072070 vs TRAF3IP1_S476 — LUAD

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