Loop of Henle development

Across TCGA cell cohorts, RNA activity of the Loop of Henle development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS16, PARP3, and FSTL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADAMTS16 grouped by Loop of Henle development-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ADAMTS16 →	-1.325	-1.372	.001	<.001	3	6
LIVER	PARP3 →	-1.851	-1.572	.003	<.001	3	5
LIVER	FSTL3 →	-2.348	-1.186	.004	.008	2	6
SKIN	ATP8B3 →	-0.624	-0.660	.007	.009	3	5
SOFT_TISSUE	NUDT22 →	-0.697	-1.358	.006	.002	3	5
BLOOD_Myeloma	CAP2 →	-1.103	-1.689	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADAMTS16 by Loop of Henle development activity — KIDNEY

Explore this box plot interactively →