S-shaped body morphogenesis

Across TCGA patient cohorts, RNA activity of the S-shaped body morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AP2M1, PYCARD, and TBX3_S456, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, S-shaped body morphogenesis activity versus AP2M1 in COAD (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	AP2M1 →	+0.168	+0.062	.004	.009	3	5
GBM	PYCARD →	-0.589	-0.140	<.001	.001	3	5
LUAD	TBX3_S456 →	+0.489	+0.116	<.001	<.001	3	5
UCEC	LGALS9 →	-0.539	-0.089	<.001	<.001	3	5
GBM	ZNF800_S317 →	-0.783	-0.164	<.001	<.001	2	6
GBM	EBNA1BP2 →	-0.422	-0.142	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072050 vs AP2M1 — COAD

Explore this scatter interactively →