S-shaped body morphogenesis

Across TCGA patient cohorts, RNA activity of the S-shaped body morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DRD5, ANKRD20A4P, and SYN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, S-shaped body morphogenesis activity versus DRD5 in BRCA (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DRD5 →	-0.047	-0.126	.006	.008	3	4
HNSC	ANKRD20A4P →	+0.496	+0.440	<.001	<.001	3	4
BRCA	SYN2 →	+0.725	+0.149	.004	.007	3	3
BRCA	ATP5PDP2 →	+1.155	+0.149	.003	.005	3	3
BRCA	RPL38P5 →	+0.752	+0.168	.001	.004	3	3
BRCA	H3P13 →	+0.615	+0.168	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072050 vs DRD5 — BRCA

Explore this scatter interactively →