Comma-shaped body morphogenesis

Across TCGA patient cohorts, RNA activity of the Comma-shaped body morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIPA1_S839, SOX9, and CENPV, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Comma-shaped body morphogenesis activity versus SIPA1_S839 in GBM (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SIPA1_S839 →	-0.428	-0.129	<.001	<.001	3	4
UCEC	SOX9 →	+0.573	+0.102	.001	.004	3	4
OV	CENPV →	+0.522	+0.064	.001	.006	3	4
HNSC	CEP192 →	+0.212	+0.076	.003	<.001	3	4
GBM	LCP1_S290 →	-0.794	-0.129	<.001	<.001	3	4
GBM	ARHGAP4 →	-0.499	-0.147	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072049 vs SIPA1_S839 — GBM

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