Comma-shaped body morphogenesis

Across TCGA patient cohorts, RNA activity of the Comma-shaped body morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02776, FABP7, and OR7E100P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Comma-shaped body morphogenesis activity versus LINC02776 in CCRCC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LINC02776 →	+0.241	+0.325	.005	.002	3	4
HNSC	FABP7 →	+2.127	+0.984	.006	<.001	3	3
CCRCC	OR7E100P →	+0.594	+0.328	.006	.004	3	3
CCRCC	NFE2L1-DT →	+0.251	+0.269	.008	.002	3	3
HNSC	MEFV →	-1.238	-0.871	.003	.003	3	2
HNSC	INO80B →	+0.550	+1.162	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072049 vs LINC02776 — CCRCC

Explore this scatter interactively →