Collecting duct development

Across TCGA patient cohorts, RNA activity of the Collecting duct development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPSECS, RASIP1, and LARP7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collecting duct development activity versus SEPSECS in LUAD (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SEPSECS →	-0.190	-0.072	.004	.003	3	5
PDAC	RASIP1 →	-0.383	-0.069	<.001	.005	3	5
COAD	LARP7 →	+0.138	+0.047	.007	.003	3	5
LSCC	PRKCH_S317 →	-0.557	-0.113	<.001	<.001	3	5
HNSC	AAAS_S495 →	+0.509	+0.092	.004	<.001	3	5
LSCC	HK2 →	+0.530	+0.143	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072044 vs SEPSECS — LUAD

Explore this scatter interactively →