Collecting duct development

Across TCGA patient cohorts, RNA activity of the Collecting duct development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGKV1D-17, C9, and TCN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collecting duct development activity versus IGKV1D-17 in BRCA (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGKV1D-17 →	-1.442	-0.568	.002	.005	3	4
LSCC	C9 →	+1.004	+0.539	<.001	.006	3	3
PDAC	TCN1 →	+0.959	+0.279	.003	<.001	3	3
PDAC	PA2G4P4 →	-0.369	-0.224	.001	.004	3	3
PDAC	CA12 →	+1.029	+0.301	.001	.006	3	3
LSCC	GSDMC →	+1.386	+0.624	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072044 vs IGKV1D-17 — BRCA

Explore this scatter interactively →