Collecting duct development

Across TCGA cell cohorts, RNA activity of the Collecting duct development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX9, OPA1, and SLC35D2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOX9 grouped by Collecting duct development-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SOX9 →	+2.700	+1.506	.007	.007	3	5
LIVER	OPA1 →	+0.623	+1.228	.001	.001	3	5
PANCREAS	SLC35D2 →	+0.974	+1.223	.004	.001	3	5
KIDNEY	CLCF1 →	+0.972	+0.498	.006	<.001	3	4
STOMACH	ARHGEF19 →	-1.038	-1.298	.005	.002	3	3
CNS	EXOC7 →	+0.557	+0.825	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOX9 by Collecting duct development activity — URINARY_TRACT

Explore this box plot interactively →