Collecting duct development

Across TCGA cell cohorts, RNA activity of the Collecting duct development pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETV6, PDYN, and SLC5A9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ETV6 grouped by Collecting duct development-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ETV6 →	+0.188	+0.153	.003	.005	3	4
OESOPHAGUS	PDYN →	+0.258	+0.255	.003	.003	3	4
LUNG_SCLC	SLC5A9 →	+0.260	+0.149	.004	.008	2	4
SKIN	PCDHB4 →	+0.166	+0.130	.002	.002	3	3
OESOPHAGUS	GDNF →	+0.359	+0.166	<.001	.007	2	4
UPPER_AERODIGESTIVE_TRACT	MMRN1 →	+0.113	+0.221	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ETV6 by Collecting duct development activity — BLOOD_Myeloma

Explore this box plot interactively →