Mesenchymal stem cell maintenance involved in nephron morphogenesis

pathway activity — cross-omics
GO:0072038Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mesenchymal stem cell maintenance involved in nephron morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVL, RCSD1, and VASH1_S313, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCEVL →-0.532-0.462<.001<.00136
LSCCRCSD1 →-0.461-0.401<.001.00236
LSCCVASH1_S313 →-0.490-0.276<.001.00136
OVPSAT1 →+1.032+0.209.001<.00136
OVGPRIN3 →-0.492-0.100<.001.00436
LSCCWIPF1 →-0.330-0.366<.001.00436
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration