Renal vesicle formation

Across TCGA patient cohorts, RNA activity of the Renal vesicle formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2Q2, LEPROT, and GOLM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal vesicle formation activity versus UBE2Q2 in BRCA (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UBE2Q2 →	+0.701	+0.484	<.001	.008	3	5
LSCC	LEPROT →	+0.356	+0.461	.001	.001	3	4
GBM	GOLM1 →	+0.512	+0.474	.004	<.001	3	4
GBM	OFD1 →	+0.276	+0.303	.006	<.001	3	4
GBM	RBBP9 →	+0.434	+0.348	<.001	<.001	3	4
LSCC	BBS9 →	+0.294	+0.333	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072033 vs UBE2Q2 — BRCA

Explore this scatter interactively →