Nephron morphogenesis

Across TCGA patient cohorts, RNA activity of the Nephron morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GRB2, RBBP9, and SMOC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nephron morphogenesis activity versus GRB2 in GBM (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GRB2 →	-0.276	-0.050	.002	.002	3	7
BRCA	RBBP9 →	+0.267	+0.021	.001	.007	3	7
LSCC	SMOC2 →	+0.628	+0.028	<.001	<.001	3	7
PDAC	SP110_S380 →	-0.707	-0.043	<.001	<.001	3	7
BRCA	TAP1 →	-0.455	-0.022	<.001	<.001	3	7
PDAC	RCSD1_S351 →	-0.488	-0.048	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072028 vs GRB2 — GBM

Explore this scatter interactively →