Distal tubule development

Across TCGA patient cohorts, RNA activity of the Distal tubule development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPO, SNORA74C-1, and FOXO4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Distal tubule development activity versus LPO in BRCA (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LPO →	-0.214	-0.380	.005	.007	3	4
LUAD	SNORA74C-1 →	+0.299	+0.424	.006	.003	3	3
PDAC	FOXO4 →	-0.203	-0.543	.005	.006	2	4
PDAC	PCMTD2 →	-0.230	-0.518	.006	.006	3	3
PDAC	LINC00957 →	-0.306	-0.746	<.001	<.001	3	3
BRCA	BCL2L1 →	+0.327	+0.322	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072017 vs LPO — BRCA

Explore this scatter interactively →