Distal tubule development

Across TCGA cell cohorts, RNA activity of the Distal tubule development pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DELEC1, SBF1, and PIPSL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DELEC1 grouped by Distal tubule development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DELEC1 →	-0.171	-0.181	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SBF1 →	-0.169	-0.243	<.001	<.001	3	4
KIDNEY	PIPSL →	+0.270	+0.225	<.001	.003	2	5
SOFT_TISSUE	EOMES →	-0.360	-0.217	.001	.006	3	4
BREAST	WARS2 →	+0.184	+0.173	.001	.002	3	3
BREAST	NBR1 →	+0.162	+0.162	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DELEC1 by Distal tubule development activity — SKIN

Explore this box plot interactively →