Proximal tubule development

Across TCGA patient cohorts, RNA activity of the Proximal tubule development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL18A1, SMOC2, and IGFBP7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proximal tubule development activity versus COL18A1 in HNSC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	COL18A1 →	+0.414	+0.049	<.001	.001	3	8
COAD	SMOC2 →	+0.777	+0.051	<.001	<.001	3	8
UCEC	IGFBP7 →	+0.536	+0.055	<.001	.001	3	7
BRCA	MAP1A →	+0.452	+0.055	<.001	<.001	3	7
CCRCC	SEPTIN7 →	+0.195	+0.060	.001	.002	3	7
PDAC	CYBB →	-0.587	-0.043	.007	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072014 vs COL18A1 — HNSC

Explore this scatter interactively →